Genetic alterations of metabolic enzymes profoundly impact fat levels in C. elegans. For example, RNAi inactivation of key glycolic and gluconeogenic genes such as GAPDH, an insulin-regulated glycolytic enzyme, and PEPCK, a regulated enzyme of gluconeogenesis and glyceroneogenesis, cause fat reduction (Ashrafi et al., 2003).
Obesity and the regulation of fat metabolism - WormBook - NCBI Bookshelf
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